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Chemical Structure : PSB-22040
Catalog No.: PC-21319Not For Human Use, Lab Use Only.
PSB-22040 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 19.2 nM/30.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively.
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PSB-22040 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 19.2 nM/30.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively.
PSB-22040 shows high selectivity over the other MRGPRX subtypes, MRGPRX1, -2, and -3.
PSB-22040 is a promising tool compound for exploring the potential of MRGPRX4 as a future drug target.
| M.Wt | 474.45 | |
| Formula | C22H27N4O6P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Marx D, et al. J Med Chem. 2023 Nov 15. doi: 10.1021/acs.jmedchem.3c01013.
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