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PSB-22040

Chemical Structure : PSB-22040

CAS No.: 2768131-35-5

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PSB-22040 (PSB22040, PSB 22040)

Catalog No.: PC-21319Not For Human Use, Lab Use Only.

PSB-22040 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 19.2 nM/30.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PSB-22040 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 19.2 nM/30.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively.
    PSB-22040 shows high selectivity over the other MRGPRX subtypes, MRGPRX1, -2, and -3.
    PSB-22040 is a promising tool compound for exploring the potential of MRGPRX4 as a future drug target.

    Physicochemical Properties

    M.Wt 474.45
    Formula C22H27N4O6P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4-(8-(3-Methoxyphenethyl)-7-methyl-2,6-dioxo-1-(prop-2-yn-1-yl)-1,2,6,7-tetrahydro-3H-purin-3-yl)butyl)phosphonic Acid

    References

    1. Marx D, et al. J Med Chem. 2023 Nov 15. doi: 10.1021/acs.jmedchem.3c01013.

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