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PSB-24379

Chemical Structure : PSB-24379

CAS No.:

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PSB-24379 (PSB24379)

Catalog No.: PC-26703Not For Human Use, Lab Use Only.

PSB-24379 is a potent, selective inhibitor of ATP-hydrolyzing ectoenzyme nucleoside triphosphate diphosphohydrolase-1 (NTPDase1, CD39) with Ki of 77.4 nM, shows ancillary CD73 inhibition with Ki of 240 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PSB-24379 is a potent, selective inhibitor of ATP-hydrolyzing ectoenzyme nucleoside triphosphate diphosphohydrolase-1 (NTPDase1, CD39) with Ki of 77.4 nM, shows ancillary CD73 inhibition with Ki of 240 nM.
PSB-24379 reduced ATP hydrolysis in melanoma and breast cancer cell membranes and partially reverted ATP-mediated effects on T cell activation and proliferation in an ATP-rich environment.

Physicochemical Properties

M.Wt 637.65
Formula C30H32N5O7PS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

((2R,3S,4R,5R)-3,4-Dihydroxy-5-(8-(naphthalen-1-ylthio)-6-((4-phenylbutyl)amino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl dihydrogen Phosphate

References

1. Chunyang Bi, et al. J Med Chem. 2026 May 1. doi: 10.1021/acs.jmedchem.6c00054.

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