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PSI-421

Chemical Structure : PSI-421

CAS No.: 1067186-56-4

PSI-421 (PSI 421;PSI421)

Catalog No.: PC-61287Not For Human Use, Lab Use Only.

PSI-421 is a potent, orally bioavailable P-selectin inhibitor with biacore IC50 of 56 uM, shows improved pharmacokinetic properties and oral efficacy in models of vascular injury compare with PSI-697.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PSI-421 is a potent, orally bioavailable P-selectin inhibitor with biacore IC50 of 56 uM, shows improved pharmacokinetic properties and oral efficacy in models of vascular injury compare with PSI-697.

    Physicochemical Properties

    M.Wt 407.773
    Formula C20H13ClF3NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid

    References

    1. Huang A, et al. J Med Chem. 2010 Aug 26;53(16):6003-17.

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