PSI-421 | P-selectin inhibitor | Probechem Biochemicals

Chemical Structure : PSI-421

PSI-421 (PSI 421, PSI421)

Catalog No.: PC-61287Not For Human Use, Lab Use Only.

PSI-421 is a potent, orally bioavailable P-selectin inhibitor with biacore IC50 of 56 uM, shows improved pharmacokinetic properties and oral efficacy in models of vascular injury compare with PSI-697.

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Biological Activity

PSI-421 is a potent, orally bioavailable P-selectin inhibitor with biacore IC50 of 56 uM, shows improved pharmacokinetic properties and oral efficacy in models of vascular injury compare with PSI-697.

Physicochemical Properties

M.Wt	407.773
Formula	C20H13ClF3NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid

References

1. Huang A, et al. J Med Chem. 2010 Aug 26;53(16):6003-17.

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PSI-421 (PSI 421, PSI421)

Biological Activity

Physicochemical Properties

References

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