PSI-6130 (R-1656) is a potent, specific inhibitor of HCV RNA synthesis by inhibiting the NS5B RNA polymerase (EC90=4.6 uM in replicon assay).
PSI-6130 shows no anti-BVDV activity and weak antiviral activity against other flaviviruses, including West Nile virus, Dengue type 2, and yellow fever virus.
PSI-6130 has little or no cytotoxicity against various cell type.
Physicochemical Properties
M.Wt
259.2343
Formula
C10H14FN3O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Cytidine, 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-
References
1. Clark JL, et al. J Med Chem. 2005 Aug 25;48(17):5504-8.
2. Murakami E, et al. Antimicrob Agents Chemother. 2007 Feb;51(2):503-9.
3. Stuyver LJ, et al. Antivir Chem Chemother. 2006;17(2):79-87.
4. Ma H, et al. J Biol Chem. 2007 Oct 12;282(41):29812-20.
