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Chemical Structure : PSN-GK1
Catalog No.: PC-61876Not For Human Use, Lab Use Only.
PSN-GK1 is a potent, orally available Glucokinase (GK) activator with EC50 of 130 nM at 5 mM glucose (4.3-fold).
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PSN-GK1 is a potent, orally available Glucokinase (GK) activator with EC50 of 130 nM at 5 mM glucose (4.3-fold).
PSN-GK1 increases MIN6 insulin secretion (26-fold, EC50=267 nM) and 2-DG hepatocytic uptake (3-fold, EC50=1 uM).
PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions in mice.
| M.Wt | 438.532 | |
| Formula | C20H23FN2O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fyfe MC, et al. Diabetologia. 2007 Jun;50(6):1277-87.
2. Bertram LS, et al. J Med Chem. 2008 Jul 24;51(14):4340-5.
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