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PSN-GK1

Chemical Structure : PSN-GK1

CAS No.: 745051-61-0

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PSN-GK1 (PSN GK1)

Catalog No.: PC-61876Not For Human Use, Lab Use Only.

PSN-GK1 is a potent, orally available Glucokinase (GK) activator with EC50 of 130 nM at 5 mM glucose (4.3-fold).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PSN-GK1 is a potent, orally available Glucokinase (GK) activator with EC50 of 130 nM at 5 mM glucose (4.3-fold).
    PSN-GK1  increases MIN6 insulin secretion (26-fold, EC50=267 nM) and 2-DG hepatocytic uptake (3-fold, EC50=1 uM).
    PSN-GK1  displays enhanced antihyperglycaemic and insulinotropic actions in mice.

    Physicochemical Properties

    M.Wt 438.532
    Formula C20H23FN2O4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2R)-2-(4-cyclopropanesulfonylphenyl)- N-(5-fluorothiazol-2-yl)-3-(tetrahydropyran-4-yl)propionamide

    References

    1. Fyfe MC, et al. Diabetologia. 2007 Jun;50(6):1277-87.

    2. Bertram LS, et al. J Med Chem. 2008 Jul 24;51(14):4340-5.

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