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PST-1P

Chemical Structure : PST-1P

CAS No.: 1801769-45-8

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PST-1P (Microtubule photoswitchable inhibitor)

Catalog No.: PC-62673Not For Human Use, Lab Use Only.

PST-1P is a photoswitchable inhibitor of microtubule with EC50 of 0.7 uM under 390 nm irradiation in the MDA-MB-231 human breast cancer cell lines.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PST-1P is a photoswitchable inhibitor of microtubule with EC50 of 0.7 uM under 390 nm irradiation in the MDA-MB-231 human breast cancer cell lines.
    PST-1P is100-fold more cytotoxic than in the dark.
    PST-1P induces mitotic arrest and cell death in a light-dependent manner, and controls mitosis and the microtubule cytoskeleton in mammalian tissue in vivo.
    PST-1P is the highly water-soluble prodrug of PST-1.

    Physicochemical Properties

    M.Wt 398.308
    Formula C16H19N2O8P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-2-methoxy-5-((3,4,5-trimethoxyphenyl)diazenyl)phenyl dihydrogen phosphate

    References

    1. Borowiak M, et al. Cell. 2015 Jul 16;162(2):403-11.

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