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Chemical Structure : PTB1
Catalog No.: PC-23126Not For Human Use, Lab Use Only.
Peptide Targeting BamA-1 (PTB1) is a 12-amino acid macrocycle, multi-species BamA inhibitor, binds to purified BamA with SPR Kd of 50 pM, has MIC of 42 ug/mL (25 uM) against wild-type E. coli strain.
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Peptide Targeting BamA-1 (PTB1) is a 12-amino acid macrocycle, multi-species BamA inhibitor, binds to purified BamA with SPR Kd of 50 pM, has MIC of 42 ug/mL (25 uM) against wild-type E. coli strain.
PTB1 exhibits MICs against wild-type Klebsiella pneumoniae and Enterobacter cloacae, ranging from 42 to 168 µg/mL (25–100 µM), shows no MICs against the non-fermenting Gram-negative pathogens Pseudomonas aeruginosa and Acinetobacter baumannii.
PTB1-1 reduces OMP levels, decreases activity of the OmpT enzyme that requires BAM for folding, and increases OM permeability.
PTB1 targets an extracellular binding site, and acts as a state-dependent antagonist which targets the closed state of BamA.
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| Appearance | Solid | |
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10 mM in DMSO |
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