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PTC-028

Chemical Structure : PTC-028

CAS No.: 1782970-28-8

PTC-028 (PTC 028;PTC028)

Catalog No.: PC-60464Not For Human Use, Lab Use Only.

PTC-028 (PTC028) is a novel potent, selective, orally bioavailable BMI-1 inhibitor with potent anti-MM activity against primary MM cells (IC50=10-100 nM).

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Biological Activity

PTC-028 (PTC028) is a novel potent, selective, orally bioavailable BMI-1 inhibitor with potent anti-MM activity against primary MM cells (IC50=10-100 nM).
PTC-028 decreases BMI-1 levels by posttranslational modification, selectively inhibits cancer cells in clonal growth and viability assays (IC50=100 nM), without effeccts on normal cells.
PTC-028 exhibits significant antitumor activity in mouse model of ovarian cancer.

Physicochemical Properties

M.Wt 405.332
Formula C19H12F5N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-(5,6-difluoro-2-methyl-1H-benzo[d]imidazol-1-yl)-N-(4-(trifluoromethyl)phenyl)pyrazin-2-amine

References

1. Dey A, et al. Mol Cancer Ther. 2017 Nov 20. doi: 10.1158/1535-7163.MCT-17-0574.

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