Catalog No.: PC-60464Not For Human Use, Lab Use Only.
PTC-028 (PTC028) is a novel potent, selective, orally bioavailable BMI-1 inhibitor with potent anti-MM activity against primary MM cells (IC50=10-100 nM).
PTC-028 (PTC028) is a novel potent, selective, orally bioavailable BMI-1 inhibitor with potent anti-MM activity against primary MM cells (IC50=10-100 nM).
PTC-028 decreases BMI-1 levels by posttranslational modification, selectively inhibits cancer cells in clonal growth and viability assays (IC50=100 nM), without effeccts on normal cells.
PTC-028 exhibits significant antitumor activity in mouse model of ovarian cancer.
