Chemical Structure : PTX-BD4-3
CAS No.:
1627852-88-3
PTX-BD4-3
Catalog No.: PC-28534Not For Human Use, Lab Use Only.
PTX-BD4-3 is a specific small-molecule, non-peptide TrkB partial agonist, supports the survival of cultured hippocampal neurons with EC50 of 300-500 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PTX-BD4-3 is a specific small-molecule, non-peptide TrkB partial agonist, supports the survival of cultured hippocampal neurons with EC50 of 300-500 nM.
PTX-BD4-3 promotes survival of 3T3-TrkB cells in a dose-dependent manner and to a similar degree to the parent compound, LM22A-4, has no effect on survival of TrkA-, TrkC- or p75-expressing cells.
PTX-BD4-3 promotes the recruitment of the TrkB adaptor protein Shc (also known as Shc1) to TrkB, triggers activation of TrkB.
PTX-BD4-3 (50 mg/kg, i.p.) significantly increased pTrkB/TrkB and pAKT/AKT in null male Mecp2 mutant mice, and had no significant effect on pERK/ERK.
PTX-BD4-3 (5 mg/kg) reduces apneic breathing in heterozygous (Het) female Mecp2 mutants.
PTX-BD4-3 restores motor learning in Het female Mecp2 mutants.
Physicochemical Properties
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M.Wt
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423.51
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Formula
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C21H33N3O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N1,N3,N5-tris(2-methoxyethyl)-N1,N3,N5-trimethylbenzene-1,3,5-tricarboxamide
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References
1. Gu F, et al. Cereb Cortex. 2020 Jul 30;30(9):5180-5189.
2. Adams I, et al. Dis Model Mech. 2020 Nov 27;13(11):dmm044685.
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