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Chemical Structure : PU-139
CAS No.: 158093-65-3
Catalog No.: PC-61686Not For Human Use, Lab Use Only.
PU-139 is a potent, unselective HAT (Histone acetyltransferase) inhibitor that blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB protein (CBP) and p300.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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PU-139 is a potent, unselective HAT (Histone acetyltransferase) inhibitor that blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB protein (CBP) and p300.
PU-139 triggers caspase-independent cell death in cell culture, blocks growth of SK-N-SH neuroblastoma xenografts in mice, and synergizes the effect of doxorubicin in vivo.
| M.Wt | 246.259 | |
| Formula | C12H7FN2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(4-fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one |
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1. Gajer JM, et al. Oncogenesis. 2015 Feb 9;4:e137.
2. Carneiro VC, et al. PLoS Pathog. 2014 May 8;10(5):e1004116.
3. Furdas SD, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89.
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