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Chemical Structure : PU-141
CAS No.: 168334-34-7
Catalog No.: PC-61685Not For Human Use, Lab Use Only.
PU-141 is a potent, selective CBP/p300 inhibitor that inhibits SK-N-SH cell growth with GI50 of 0.48 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PU-141 is a potent, selective CBP/p300 inhibitor that inhibits SK-N-SH cell growth with GI50 of 0.48 uM.
PU-141 blocks growth of SK-N-SH neuroblastoma xenografts in mice.
PU-141 also reduces histone lysine acetylation in vivo at concentrations that block neoplastic xenograft growth.
| M.Wt | 310.294 | |
| Formula | C14H9F3N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(4-(trifluoromethyl)benzyl)isothiazolo[5,4-b]pyridin-3(2H)-one |
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1. Gajer JM, et al. Oncogenesis. 2015 Feb 9;4:e137.
2. Furdas SD, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89.
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