Chemical Structure : PU-48
CAS No.:
335394-78-0
PU-48
Catalog No.: PC-26600Not For Human Use, Lab Use Only.
PU-48 is a selective inhibitor of urea transporters UT-A and UT-B with IC50 of 0.32 uM (UT-A1), inhibits UT-B-facilitated urea transport with IC50 of 0.21 uM, 0.21 in human, 0.33 uM in rat, and 2.1 uM for human, rat, and mouse.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PU-48 is a selective inhibitor of urea transporters UT-A and UT-B with IC50 of 0.32 uM (UT-A1), inhibits UT-B-facilitated urea transport with IC50 of 0.21 uM, 0.21 in human, 0.33 uM in rat, and 2.1 uM for human, rat, and mouse.
PU-48 does not affect non-UT-B-mediated transmembrane urea transport in erythrocytes.
PU-48 inhibits urea transport in rat terminal inner medullary collecting ducts (IMCDs).
PU-48 (100 mg/kg) significantly increased urea excretion in both wild-type mice and UT-B-null mice, did not change blood Na+, K+, or Cl− levels or nonurea solute excretion in rats and mice.
Physicochemical Properties
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M.Wt
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288.32
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Formula
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C14H12N2O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl 3-amino-6-methoxythieno[2,3-b]quinoline-2-carboxylate
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References
1. Zhang ZY, et al. Pharmaceutics. 2018 Aug 8;10(3):124.
2. Ren H, et al. Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1363-72.
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