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PUC-10

Chemical Structure : PUC-10

CAS No.: 2064126-76-5

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PUC-10

Catalog No.: PC-24220Not For Human Use, Lab Use Only.

PUC-10 is a selective 5-HT6 receptor antagonist high binding affinity (Ki=14.6 nM) and IC50 of 32 nM in calcium mobilisation functional assay, induces mTOR-dependent autophagy.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PUC-10 is a selective 5-HT6 receptor antagonist high binding affinity (Ki=14.6 nM) and IC50 of 32 nM in calcium mobilisation functional assay, induces mTOR-dependent autophagy.

Physicochemical Properties

M.Wt 541.67
Formula C31H31N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-(2-methoxyphenyl)piperazin-1-yl)-1-(1-(naphthalen-1-ylsulfonyl)-1 H-indol-3-yl)ethan-1-ol

References

1. Alcaíno JM, et al. Sci Rep. 2025 Mar 11;15(1):8380. doi: 10.1038/s41598-025-92755-6.

2. Vera, G. et al. Extended N-Arylsulfonylindoles as 5-HT6 receptor antagonists: design, synthesis and biological evaluation. Molecules 21 (8). https://doi.org/10.3390/molecules21081070 (2016).

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