Chemical Structure : PW164
CAS No.:
2459268-10-9
PW164
(PW-164)
Catalog No.: PC-25069Not For Human Use, Lab Use Only.
PW164 is a specific, small molecule inhibitor of FGF13/Nav1.7 channel C-terminal tail domain (CTD) PPI interface with IC50 of 29 uM (FGF13/Nav1.7 complex assembly), selectively modulates Nav1.7 currents.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PW164 is a specific, small molecule inhibitor of FGF13/Nav1.7 channel C-terminal tail domain (CTD) PPI interface with IC50 of 29 uM (FGF13/Nav1.7 complex assembly), selectively modulates Nav1.7 currents.
PW164 selectively suppresses capsaicin-induced signaling in hIPSC-derived sensory neurons.
PW164 displays appreciable binding for FGF13 (KD of 21 μM) but shows no interaction with Nav1.7 CTD.
PW164 reverses FGF13-induced increase in INa density dose dependently, with an IC50 of 6.74 μM and induces LTI while decelerating Nav1.7 repriming.
PW164 is an FGF13-dependent analgesic that preserves normal sensory function, exerts antinociceptive effects and mimics in vivo FGF13 knockdown.
PW164 (15 mg/kg, i.d.) reduces mechanical hyperalgesia in the HFD-induced T2DN mouse model.
Physicochemical Properties
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M.Wt
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660.81
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Formula
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C34H52N4O9
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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benzyl (S)-2-(((S)-1-(((S)-5-(tert-butoxy)-1-(((S)-1-methoxy-3-methyl-1-oxobutan-2-yl)amino)-1,5-dioxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carboxylate
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References
1. Singh AK, et al. J Clin Invest. 2025 Jul 15;135(14):e183749.
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