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PZ-1922

Chemical Structure : PZ-1922

CAS No.: 1648745-65-6

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PZ-1922 (PZ1922)

Catalog No.: PC-21667Not For Human Use, Lab Use Only.

PZ-1922 is a potent, triple-acting 5-HT6R/5-HT3R antagonist and MAO-B reversible inhibitor with Ki of 17/0.45 nM (5-HT6R/5-HT3R), and pIC50 of 8.93 for MAO-B.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PZ-1922 is a potent, triple-acting 5-HT6R/5-HT3R antagonist and MAO-B reversible inhibitor with Ki of 17/0.45 nM (5-HT6R/5-HT3R), and pIC50 of 8.93 for MAO-B.
PZ-1922 reversed scopolamine-induced cognitive deficits in the novel object recognition test. Furthermore, it displayed superior pro-cognitive properties compared to intepirdine (a 5-HT6R antagonist) in the AD model.
PZ-1922, but not intepirdine, restored levels of biomarkers characteristic of the debilitating effects of oAβ.

Physicochemical Properties

M.Wt 376.89
Formula C22H21ClN4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3-Chlorobenzyl)-4-(piperazin-1-yl)-1H-pyrrolo[3,2-c]quinoline

References

1. Katarzyna Grychowska, et al. J Med Chem. 2023 Nov 9;66(21):14928-14947.

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