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Pactamycin

Chemical Structure : Pactamycin

CAS No.: 23668-11-3

Pactamycin (NSC 52947)

Catalog No.: PC-62849Not For Human Use, Lab Use Only.

Pactamycin (NSC 52947) is a potent protein synthesis inhibitor, inhibits protein synthesis at the translocation step on the 70S ribosome, has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial activity.

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    Biological Activity

    Pactamycin (NSC 52947) is a potent protein synthesis inhibitor, inhibits protein synthesis at the translocation step on the 70S ribosome, has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial activity.

    Physicochemical Properties

    M.Wt 558.62
    Formula C28H38N4O8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    [(1S,2R,3R,4S,5S)-5-(3-acetylanilino)-4-amino-3-(dimethylcarbamoylamino)-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methyl 2-hydroxy-6-methylbenzoate

    References

    1. Bhuyan BK. Biochem Pharmacol. 1967 Aug;16(8):1411-20.

    2. Suzuki H, et al. Proc Natl Acad Sci U S A. 1974 Oct;71(10):4259-63.

    3. Kappen LS, et al. Biochemistry. 1976 Feb 24;15(4):811-8.

    4. Hanessian S, et al. Bioorg Med Chem. 2013 Apr 1;21(7):1775-86.

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