Catalog No.: PC-28420Not For Human Use, Lab Use Only.
Paeoniflorigenone (PAG) is a monoterpene compound found in the root of moutan cortex, inhibits the proliferation of tumor cells, directly binds to TRIM28, triggering its phosphorylation at Ser824, induces ferroptosis.
Paeoniflorigenone (PAG) is a monoterpene compound found in the root of moutan cortex, inhibits the proliferation of tumor cells, directly binds to TRIM28, triggering its phosphorylation at Ser824, induces ferroptosis. Paeoniflorigenone alleviates repressive H3K9me3 occupancy at the HMOX1 promoter, thereby unlocking local chromatin accessibility to drive HMOX1 transcription and culminate in ferroptosis. Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/beta-catenin pathway. Paeoniflorigenone inhibits the progression of cholangiocarcinoma via HIF1A and enhances the chemotherapy sensitivity of cisplatin.
