Pamapimod |CAS:449811-01-2 Probechem Biochemicals

Chemical Structure : Pamapimod

CAS No.: 449811-01-2

Pamapimod (Ro4402257;R1503)

Catalog No.: PC-42565Not For Human Use, Lab Use Only.

Pamapimod (Ro4402257; R1503) is a potent, selective, orally bioavailable p38α MAPK inhibitor with Kd of 0.2 nM.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$198	In stock
50 mg	$298	In stock
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Biological Activity

Pamapimod (Ro4402257; R1503) is a potent, selective, orally bioavailable p38α MAPK inhibitor with Kd of 0.2 nM.
Pamapimod (Ro4402257; R1503) displays >100 fold selectivity over p38β (Kd=29 nM), and no affinity against p38γ, p38δ and a broad panel of kianses.
Pamapimod (Ro4402257; R1503) inhibits LPS-stimulated TNF-alpha production by monocytes, IL-1beta production in human whole blood.
Pamapimod (Ro4402257; R1503) exhibits the ability to inhibit the signs and symptoms of RA and other autoimmune diseases.

Physicochemical Properties

M.Wt	406.3833
Formula	C19H20F2N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,4-difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methyl-

References

1. Goldstein DM, et al. J Med Chem. 2011 Apr 14;54(7):2255-65.

2. Hill RJ, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):610-9.

3. Cohen SB, et al. Arthritis Rheum. 2009 Feb;60(2):335-44.

Pamapimod (Ro4402257;R1503)

Biological Activity

Physicochemical Properties

References

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