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Chemical Structure : Panobinostat
CAS No.: 404950-80-7
Catalog No.: PC-42468Not For Human Use, Lab Use Only.
A potent, broad-spectrum HDAC inhibitor with IC50 of 5-20 nM in cell-free assyas.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $120 | In stock | |
| 200 mg | $200 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
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Panobinostat (LBH589, NVP-LBH589) is a potent, broad-spectrum HDAC inhibitor with IC50 of 5-20 nM in cell-free assyas.
Panobinostat (LBH589, NVP-LBH589) induces cell-cycle arrest, apoptosis, and histone (H3K9 and H4K8) hyperacetylation.
Panobinostat (LBH589, NVP-LBH589) increases mRNA levels of proapoptosis, growth arrest, and DNA damage repair genes including FANCG, FOXO3A, GADD45A, GADD45B, and GADD45G.
Panobinostat (LBH589, NVP-LBH589) significantly slows tumor growth derived from Meso and NSCLC cells in vivo models.
| M.Wt | 349.4262 | |
| Formula | C21H23N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 57 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- |
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1. Crisanti MC, et al. Mol Cancer Ther. 2009 Aug;8(8):2221-31.
2. George P, et al. Blood. 2005 Feb 15;105(4):1768-76.
3. Scuto A, et al. Blood. 2008 May 15;111(10):5093-100.
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