Paritaprevir | HCV NS3/4A inhibitor | Probechem Biochemicals

Chemical Structure : Paritaprevir

CAS No.: 1216941-48-8

Paritaprevir (ABT-450, Veruprevir, ABT450)

Catalog No.: PC-43117Not For Human Use, Lab Use Only.

Paritaprevir (ABT-450, Veruprevir) is a potent HCV NS3/4A protease inhibitor with EC50 of 1 and 0.21 nM for HCV GT 1a and 1b, respectively.

Packing	Price	Stock
5 mg	$118	In stock
10 mg	$188	In stock
25 mg	$298	In stock
50 mg	$488	In stock
100 mg	$758	In stock
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Biological Activity

Paritaprevir (ABT-450, Veruprevir) is a potent HCV NS3/4A protease inhibitor with EC50 of 1 and 0.21 nM for HCV GT 1a and 1b, respectively.
Paritaprevir demonstrates in vitro antiviral activity against HCV GT1-4 and GT6 (EC50=0.09 to 19 nM), and an EC50 of 0.09 nM against GT4a.
The combination of paritaprevir, ritonavir, ombitasvir (an NS5A protein inhibitor), and dasabuvir (an NS5B non-nucleoside polymerase inhibitor) with or without RBV has been approved to treat HCV genotype 1 infections.

Physicochemical Properties

M.Wt	765.8771
Formula	C40H43N7O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide, N-(cyclopropylsulfonyl)-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydro-6-[[(5-methyl-2-pyrazinyl)carbonyl]amino]-5,16-dioxo-2-(6-phenanthridinyloxy)-, (2R,6S,12Z,13aS,14aR,16a

References

1. Schnell G, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):6807-15.

2. Carrion AF, et al. Expert Opin Pharmacother. 2014 Apr;15(5):711-6.

3. Zeuzem S, et al. N Engl J Med. 2014 Apr 24;370(17):1604-14.

4. Andreone P, et al. Gastroenterology. 2014 Aug;147(2):359-365.e1.

Paritaprevir (ABT-450, Veruprevir, ABT450)

Biological Activity

Physicochemical Properties

References

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