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Paroxetine

Chemical Structure : Paroxetine

CAS No.: 61869-08-7

Paroxetine (BRL29060)

Catalog No.: PC-23760Not For Human Use, Lab Use Only.

Paroxetine hydrochloride is an oral, selective serotonin reuptake inhibitor (SSRI), also is a direct, selective inhibitor of G protein-coupled receptor kinase 2 (GRK2) with pIC50 of 5.6.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Paroxetine hydrochloride is an oral, selective serotonin reuptake inhibitor (SSRI), also is a direct, selective inhibitor of G protein-coupled receptor kinase 2 (GRK2) with pIC50 of 5.6.
Paroxetine also is a weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity,
Paroxetine induces autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder.

Physicochemical Properties

M.Wt 329.37
Formula C19H20FNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

References

1. Thal DM, et al. ACS Chem Biol. 2012 Nov 16;7(11):1830-9.

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