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Paroxetine hydrochloride

Chemical Structure : Paroxetine hydrochloride

CAS No.: 78246-49-8

Paroxetine hydrochloride (BRL29060 hydrochloride;BRL29060A)

Catalog No.: PC-46649Not For Human Use, Lab Use Only.

Paroxetine hydrochloride (BRL29060 hydrochloride) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Paroxetine hydrochloride (BRL29060 hydrochloride) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
Paroxetine hydrochloride also shows to be a selective inhibitor of GRK2 activity both in vitro and in living cells.
Paroxetine hydrochloride induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder.

Physicochemical Properties

M.Wt 365.8264
Formula C19H21ClFNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 250 mg/mL; H2O: 2.12 mg/mL

Chemical Name/SMILES

Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, hydrochloride (1:1), (3S,4R)-

References

1. Thal DM, et al. ACS Chem Biol. 2012 Nov 16;7(11):1830-9.

2. Gassen NC, et al. Autophagy. 2015;11(3):578-80.

3. Alcocer-Gómez E, et al. Pharmacol Res. 2017 Jul;121:114-121.

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