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Pasireotide

Chemical Structure : Pasireotide

CAS No.: 396091-73-9

Pasireotide (SOM-230, SOM320)

Catalog No.: PC-44950Not For Human Use, Lab Use Only.

A potent, stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (pKi=8.2/9.0/9.1/<7.0/9.9 for sst1/2/3/4/5, respectively).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Pasireotide (SOM230) is a potent, stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (pKi=8.2/9.0/9.1/<7.0/9.9 for sst1/2/3/4/5, respectively).
Pasireotide (SOM230) effectively inhibits GHRH-induced growth hormone release in primary cultures of rat pituitary cells with IC50 of 0.4 nM.
Pasireotide (SOM230) also potently suppresses GH secretion in rats.

Physicochemical Properties

M.Wt 1047.206
Formula C58H66N10O9
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-tyrosyl-L-phenylalanyl-(4R)-4-[[[(2-aminoethyl)amino]carbonyl]oxy]-L-prolyl]

References

1. Lewis I, et al. J Med Chem. 2003 Jun 5;46(12):2334-44.

2. Bruns C, et al. Eur J Endocrinol. 2002 May;146(5):707-16.

3. Hofland LJ, et al. Eur J Endocrinol. 2005 Apr;152(4):645-54.

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