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Chemical Structure : Pasireotide
CAS No.: 396091-73-9
Catalog No.: PC-44950Not For Human Use, Lab Use Only.
A potent, stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (pKi=8.2/9.0/9.1/<7.0/9.9 for sst1/2/3/4/5, respectively).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $268 | In stock | |
| 10 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Pasireotide (SOM230) is a potent, stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (pKi=8.2/9.0/9.1/<7.0/9.9 for sst1/2/3/4/5, respectively).
Pasireotide (SOM230) effectively inhibits GHRH-induced growth hormone release in primary cultures of rat pituitary cells with IC50 of 0.4 nM.
Pasireotide (SOM230) also potently suppresses GH secretion in rats.
| M.Wt | 1047.206 | |
| Formula | C58H66N10O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-tyrosyl-L-phenylalanyl-(4R)-4-[[[(2-aminoethyl)amino]carbonyl]oxy]-L-prolyl] |
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1. Lewis I, et al. J Med Chem. 2003 Jun 5;46(12):2334-44.
2. Bruns C, et al. Eur J Endocrinol. 2002 May;146(5):707-16.
3. Hofland LJ, et al. Eur J Endocrinol. 2005 Apr;152(4):645-54.
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