Pasireotide L-aspartate salt |CAS:396091-77-3 Probechem Biochemicals

Chemical Structure : Pasireotide L-aspartate salt

Pasireotide L-aspartate salt (SOM230 L-aspartate)

Catalog No.: PC-46000Not For Human Use, Lab Use Only.

Pasireotide (SOM230) L-aspartate is a potent, stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (pKi=8.2/9.0/9.1/<7.0/9.9 for sst1/2/3/4/5, respectively).

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Biological Activity

Pasireotide (SOM230) L-aspartate is a potent, stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (pKi=8.2/9.0/9.1/<7.0/9.9 for sst1/2/3/4/5, respectively).
Pasireotide effectively inhibits GHRH-induced growth hormone release in primary cultures of rat pituitary cells with IC50 of 0.4 nM, also potently suppresses GH secretion in rats.

Physicochemical Properties

M.Wt	1180.309
Formula	C62H73N11O13
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-tyrosyl-L-phenylalanyl-(4R)-4-[[[(2-aminoethyl)amino]carbonyl]oxy]-L-prolyl], L-aspartate (1:x)

References

1. Lewis I, et al. J Med Chem. 2003 Jun 5;46(12):2334-44.

2. Bruns C, et al. Eur J Endocrinol. 2002 May;146(5):707-16.

3. Hofland LJ, et al. Eur J Endocrinol. 2005 Apr;152(4):645-54.

Pasireotide L-aspartate salt (SOM230 L-aspartate)

Biological Activity

Physicochemical Properties

References

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