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Chemical Structure : Pavurutamab
Catalog No.: PC-38864Not For Human Use, Lab Use Only.
Pavurutamab (AMG 701) is a half-life extended anti-BCMA BiTE (bispecific T-cell engager) recombinant antibody, induces selective cytotoxicity against BCMA-expressing MM cells (EC50=18.8 pM), T-cell activation, and cytokine release in vitro and in vivo.
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| 1 mg | Get quote | ||
| 5 mg | Get quote | ||
| 10 mg | Get quote | ||
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Pavurutamab (AMG 701) is a half-life extended anti-BCMA BiTE (bispecific T-cell engager) recombinant antibody, induces selective cytotoxicity against BCMA-expressing MM cells (EC50=18.8 pM), T-cell activation, and cytokine release in vitro and in vivo.
Pavurutamab (AMG 701) completely inhibited tumor formation, as well as inhibited growth of established tumors and extended survival in an orthotopic MM model.
Combination with a programmed cell death protein 1 (PD-1)-blocking antibody significantly increased AMG 701 potency in vitro.
Isotype: Immunoglobulin scFv-scFv-scFc.
Anti-[human TNFRSF17 (TNF receptor superfamily member 17, tumor necrosis factor receptor superfamily, member 17, B cell maturation antigen, BCMA, BCM, TNFRSF13A, CD269)] and anti-[human CD3E (CD3 epsilon, Leu-4)], monoclonal antibody single chain (scFv)2-scFc, bispecific.
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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