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Paxilline

Chemical Structure : Paxilline

CAS No.: 57186-25-1

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Paxilline

Catalog No.: PC-70220Not For Human Use, Lab Use Only.

Paxilline is a potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels that binds to the α-subunit of BKCa with Ki of 1.9 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Paxilline is a potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels that binds to the α-subunit of BKCa with Ki of 1.9 nM.
Paxilline also enhances TRAIL-mediated apoptosis of glioma cells via modulation of c-FLIP, survivin and DR5.

Physicochemical Properties

M.Wt 435.56
Formula C27H33NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,4bS,6aS,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one

References

1. Kang YJ, et al. Exp Mol Med. 2011 Jan 31;43(1):24-34.

2. Sanchez M, et al. Neuropharmacology. 1996;35(7):963-8.

3. Zhou Y, et al. J Gen Physiol. 2014 Nov;144(5):415-40.

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