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Chemical Structure : Paxilline
CAS No.: 57186-25-1
Catalog No.: PC-70220Not For Human Use, Lab Use Only.
Paxilline is a potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels that binds to the α-subunit of BKCa with Ki of 1.9 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $198 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote |
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Paxilline is a potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels that binds to the α-subunit of BKCa with Ki of 1.9 nM.
Paxilline also enhances TRAIL-mediated apoptosis of glioma cells via modulation of c-FLIP, survivin and DR5.
| M.Wt | 435.56 | |
| Formula | C27H33NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R,4bS,6aS,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one |
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1. Kang YJ, et al. Exp Mol Med. 2011 Jan 31;43(1):24-34.
2. Sanchez M, et al. Neuropharmacology. 1996;35(7):963-8.
3. Zhou Y, et al. J Gen Physiol. 2014 Nov;144(5):415-40.
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