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Chemical Structure : Perlapine
Catalog No.: PC-62934Not For Human Use, Lab Use Only.
Perlapine (AW-14233, HF-2333, Hypnodine) is a potent antihistamine that has high affinity for dopamine D1, α1, α2 and 5-HT2A receptors with IC50 of 198, 19, 4945 and 70 nM, respectively.
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Perlapine (AW-14233, HF-2333, Hypnodine) is a potent antihistamine that has high affinity for dopamine D1, α1, α2 and 5-HT2A receptors with IC50 of 198, 19, 4945 and 70 nM, respectively.
Perlapine (AW-14233, HF-2333, Hypnodine) also has anticholinergic, antiserotonergic, antiadrenergic and antidopaminergic activity.
Perlapine (AW-14233, HF-2333, Hypnodine) also is a highly potent hM3Dq agonist (EC50=2.8 nM) but do not activate the native human M3 receptor (hM3, EC50>30 uM).
| M.Wt | 291.398 | |
| Formula | C19H21N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stille G, et al. Psychopharmacologia. 1973 Feb 20;28(4):325-37.
2. Wilk S, et al. Eur J Pharmacol. 1977 Jan 7;41(1):65-72.
3. Chen X, et al. ACS Chem Neurosci. 2015 Mar 18;6(3):476-84.
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