Perlapine |CAS:1977-11-3 Probechem Biochemicals

Chemical Structure : Perlapine

Perlapine (AW-14233, HF-2333, Hypnodine)

Catalog No.: PC-62934Not For Human Use, Lab Use Only.

Perlapine (AW-14233, HF-2333, Hypnodine) is a potent antihistamine that has high affinity for dopamine D1, α1, α2 and 5-HT2A receptors with IC50 of 198, 19, 4945 and 70 nM, respectively.

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Biological Activity

Perlapine (AW-14233, HF-2333, Hypnodine) is a potent antihistamine that has high affinity for dopamine D1, α1, α2 and 5-HT2A receptors with IC50 of 198, 19, 4945 and 70 nM, respectively.
Perlapine (AW-14233, HF-2333, Hypnodine) also has anticholinergic, antiserotonergic, antiadrenergic and antidopaminergic activity.
Perlapine (AW-14233, HF-2333, Hypnodine) also is a highly potent hM3Dq agonist (EC50=2.8 nM) but do not activate the native human M3 receptor (hM3, EC50>30 uM).

Physicochemical Properties

M.Wt	291.398
Formula	C19H21N3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine

References

1. Stille G, et al. Psychopharmacologia. 1973 Feb 20;28(4):325-37.

2. Wilk S, et al. Eur J Pharmacol. 1977 Jan 7;41(1):65-72.

3. Chen X, et al. ACS Chem Neurosci. 2015 Mar 18;6(3):476-84.

Perlapine (AW-14233, HF-2333, Hypnodine)

Biological Activity

Physicochemical Properties

References

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