Chemical Structure : PevD1-NRP inhibitor A6
CAS No.:
PevD1-NRP inhibitor A6
Catalog No.: PC-27711Not For Human Use, Lab Use Only.
PevD1-NRP inhibitor A6 is a specific small molecule inhibitor of Verticillium dahliae effector protein PevD1-NRP interaction, specifically binds to PevD1 (SPR KD=35.3 uM), effectively blocks the PevD1-NRP complex formation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PevD1-NRP inhibitor A6 is a specific small molecule inhibitor of Verticillium dahliae effector protein PevD1-NRP interaction, specifically binds to PevD1 (SPR KD=35.3 uM), effectively blocks the PevD1-NRP complex formation.
A6 forms stable hydrogen bonds with the key residue E108, effectively inhibiting the interaction of the PevD1-NRP.
A6 exerts anti-verticillium wilt effects caused by Verticillium dahliae infection in plants.
Fungal effector protein PevD1 promotes disease progression by interacting with the host asparagine-rich protein (NRP) and disrupting cryptochrome 2 (CRY2)-mediated signaling.
Physicochemical Properties
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M.Wt
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400.49
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Formula
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C21H24N2O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(2-((5-(4-(1-hydroxyethyl)phenyl)furan-2-yl)(methyl)amino)ethyl)benzenesulfonamide
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References
1. Yang X, et al. J Biol Chem. 2026 Aug 10:113431.
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