Catalog No.: PC-45069Not For Human Use, Lab Use Only.
Pexidartinib (PLX3397) is an oral-active, BBB-penatrant, potent mutil-targeted RTK inhibitor of CSF-1R, Kit, and Flt3 with IC50 of 20 nM, 10 nM and 160 nM, respectively.
Pexidartinib (PLX3397) is an oral-active, BBB-penatrant, potent mutil-targeted RTK inhibitor of CSF-1R, Kit, and Flt3 with IC50 of 20 nM, 10 nM and 160 nM, respectively.
Pexidartinib (PLX3397) inhibits the CSF1-dependent proliferation with IC50 of 0.44 uM, 0.22 uMand 0.1 uM in M-NFS-60, Bac1.2F5 and M-07e cells, respectively.
Pexidartinib (PLX3397) significantly inhibits PTX-induced tumor infiltration in mice.
