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Chemical Structure : Pexidartinib
CAS No.: 1029044-16-3
Catalog No.: PC-45069Not For Human Use, Lab Use Only.
Pexidartinib (PLX3397) is an oral-active, BBB-penatrant, potent mutil-targeted RTK inhibitor of CSF-1R, Kit, and Flt3 with IC50 of 20 nM, 10 nM and 160 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $288 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Pexidartinib (PLX3397) is an oral-active, BBB-penatrant, potent mutil-targeted RTK inhibitor of CSF-1R, Kit, and Flt3 with IC50 of 20 nM, 10 nM and 160 nM, respectively.
Pexidartinib (PLX3397) inhibits the CSF1-dependent proliferation with IC50 of 0.44 uM, 0.22 uMand 0.1 uM in M-NFS-60, Bac1.2F5 and M-07e cells, respectively.
Pexidartinib (PLX3397) significantly inhibits PTX-induced tumor infiltration in mice.
| M.Wt | 417.8148 | |
| Formula | C20H15ClF3N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinemethanamine, N-[5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)- |
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1. DeNardo DG, et al. Cancer Discov. 2011 Jun;1(1):54-67.
2. Coniglio SJ, et al. Mol Med. 2012 May 9;18:519-27.
3. Chitu V, et al. Blood. 2012 Oct 11;120(15):3126-35.
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