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Chemical Structure : Ph-HTBA
Catalog No.: PC-49435Not For Human Use, Lab Use Only.
Ph-HTBA is a mid-nanomolar affinity (Ki=78nM), brain permeable ligand of CaMKIIα hub domain binding site.
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Ph-HTBA is a mid-nanomolar affinity (Ki=78nM), brain permeable ligand of CaMKIIα hub domain binding site.
Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice.
Ph-HTBA is a promising candidate for CaMKIIα-associated pharmacological interventions and future clinical development.
Ph-HTBA reduces Ca2+-stimulated CaMKIIα Thr286 autophosphorylation in primary cortical neurons and substrate phosphorylation of recombinant CaMKIIα, potentially contributing to its neuroprotective effect.
| M.Wt | 294.350 | |
| Formula | C19H18O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tian Y, et al. J Med Chem. 2022 Nov 8. doi: 10.1021/acs.jmedchem.2c00805.
2. Griem-Krey N, et al. Biomed Pharmacother. 2022 Oct 20;156:113895.
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