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Phenamil methanesulfonate

Chemical Structure : Phenamil methanesulfonate

CAS No.: 1161-94-0

Phenamil methanesulfonate

Catalog No.: PC-23761Not For Human Use, Lab Use Only.

Phenamil methanesulfonate is a potent, reversible epithelial sodium channel (ENaC) blocker with IC50 of 400 nM, is also a competive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca2+ transport with IC50 of 140 nM in Ca2+ uptake assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Phenamil methanesulfonate is a potent, reversible epithelial sodium channel (ENaC) blocker with IC50 of 400 nM, is also a competive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca2+ transport with IC50 of 140 nM in Ca2+ uptake assay.

Physicochemical Properties

M.Wt 401.83
Formula C13H16ClN7O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3,5-Diamino-6-chloro-N-(N-phenylcarbamimidoyl)pyrazine-2-carboxamide methanesulfonate

References

1. Xiao-Qing Dai , et al. Mol Pharmacol. . 2007 Dec;72(6):1576-85.

2. Andrew J Hirsh, et al. J Med Chem. 2006 Jul 13;49(14):4098-115.

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