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Chemical Structure : Phenylacetamide 2
Catalog No.: PC-20441Not For Human Use, Lab Use Only.
Phenylacetamide 2 (FFA2 allosteric agonist 2) is a potent, specific and allosteric agonist of FFA2 (GPR43) with cAMP IC50 of 0.48 and 0.66 uM for hFFA2 and mFFA2, respectively.
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Phenylacetamide 2 (FFA2 allosteric agonist 2) is a potent, specific and allosteric agonist of FFA2 (GPR43) with cAMP IC50 of 0.48 and 0.66 uM for hFFA2 and mFFA2, respectively.
Phenylacetamide 2 is inactive against a panel of GPCRs that included FFA1, FFA3, GPR109A, growth hormone secretagogue receptor, endothelin type B receptor, CCR2, CXCR3, CXCR4, and CCR7 at 30 uM.
Phenylacetamide 2 is capable of activating both Gαq- and Gαi -coupled pathways for receptor function.
Phenylacetamide 2 inhibits lipolysis in 3T3L1 adipocytes in a concentration-dependent manner as measured by the reduction of glycerol production in adipocytes.
| M.Wt | 312.79 | |
| Formula | C14H14ClFN2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Taeweon Lee, et al. Mol Pharmacol. 2008 Dec;74(6):1599-609.
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