Philanthotoxin-74 (PhTx-74) | GluA2-containing AMPARs antagonist

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Chemical Structure : Philanthotoxin-74

CAS No.: 1227301-51-0

Philanthotoxin-74 (Philanthotoxin 74, PhTx-74)

Catalog No.: PC-28482Not For Human Use, Lab Use Only.

Philanthotoxin-74 (PhTx-74) is a specific antagonist of GluA2-containing AMPARs, inhibiting GluR1/2, but not GluR2/3 receptors, inhibits homomeric GluA1 and GluA3 receptors nonselectively with IC50 in the nanomolar range (252-356 nM), and heteromeric GluA1/A2 and GluA2/A3 receptors nonselectively, with IC50 in the micromolar range (22 μM).

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25 mg	$148	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Philanthotoxin-74 (PhTx-74) is a specific antagonist of GluA2-containing AMPARs, inhibiting GluR1/2, but not GluR2/3 receptors, inhibits homomeric GluA1 and GluA3 receptors nonselectively with IC50 in the nanomolar range (252-356 nM), and heteromeric GluA1/A2 and GluA2/A3 receptors nonselectively, with IC50 in the micromolar range (22 μM).

Physicochemical Properties

M.Wt	507.54
Formula	C24H44Cl2N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-alpha-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride

References

1. Poulsen MH, et al. Mol Pharmacol. 2014 Feb;85(2):261-8.

2. Kromann H, et al. J Med Chem. 2002;45:5745–5754.

3. Aaron Nilsen, et al. J Am Chem Soc. 2007 Apr 25;129(16):4902-3.

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Philanthotoxin-74 (Philanthotoxin 74, PhTx-74)

Biological Activity

Physicochemical Properties

References

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