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Phloretin

Chemical Structure : Phloretin

CAS No.: 60-82-2

Phloretin (NSC 407292, RJC 02792)

Catalog No.: PC-24599Not For Human Use, Lab Use Only.

Phloretin (NSC 407292, RJC 02792) is a small molecule inhibitor of Na+ /H+ antiporter NHA2 (SLC9B2), also is a specific, competitive and orally active inhibitor of SGLT1 and SGLT2, shows anti-inflammatory activities.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Phloretin (NSC 407292, RJC 02792) is a small molecule inhibitor of Na+ /H+ antiporter NHA2 (SLC9B2), also is a specific, competitive and orally active inhibitor of SGLT1 and SGLT2, shows anti-inflammatory activities.
Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50 of 49 μM and 61 μM, respectively.
Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation.

Physicochemical Properties

M.Wt 274.27
Formula C15H14O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one

References

1. Kasahara T, et al. Biochem J. 1996 Apr 1;315 ( Pt 1):177-82.

2. Jung S, et al. Int J Mol Sci. 2025 Apr 29;26(9):4221.

3. Wang SP, et al. Evid Based Complement Alternat Med. 2016;2016:9831263.

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