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Phosphonoacetohydroxamate

Chemical Structure : Phosphonoacetohydroxamate

CAS No.: 89893-77-6

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Phosphonoacetohydroxamate (PhAH)

Catalog No.: PC-62307Not For Human Use, Lab Use Only.

Phosphonoacetohydroxamate (PhAH) is a potent Enolase inhibitor with IC50 of 53.2 nM and 62.3 nM for recombinant hENO1 and hENO2 respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Phosphonoacetohydroxamate (PhAH) is a potent Enolase inhibitor with IC50 of 53.2 nM and 62.3 nM for recombinant hENO1 and hENO2 respectively.
    Phosphonoacetohydroxamate (PhAH) shows selectively toxic to ENO1-deleted GBM cells relative to ENO1-intact GBM cells or normal astrocytes.

    Physicochemical Properties

    M.Wt 155.046
    Formula C2H6NO5P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl methyl diethylphosphoramidate

    References

    1. Poyner RR, et al. Biochemistry. 1992 Aug 11;31(31):7166-73.

    2. Leonard PG, et al. Nat Chem Biol. 2016 Dec;12(12):1053-1058.

    3. Muller FL, et al. Nature. 2012 Aug 16;488(7411):337-42.

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