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Chemical Structure : Phosphonoacetohydroxamate
Catalog No.: PC-62307Not For Human Use, Lab Use Only.
Phosphonoacetohydroxamate (PhAH) is a potent Enolase inhibitor with IC50 of 53.2 nM and 62.3 nM for recombinant hENO1 and hENO2 respectively.
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Phosphonoacetohydroxamate (PhAH) is a potent Enolase inhibitor with IC50 of 53.2 nM and 62.3 nM for recombinant hENO1 and hENO2 respectively.
Phosphonoacetohydroxamate (PhAH) shows selectively toxic to ENO1-deleted GBM cells relative to ENO1-intact GBM cells or normal astrocytes.
| M.Wt | 155.046 | |
| Formula | C2H6NO5P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Poyner RR, et al. Biochemistry. 1992 Aug 11;31(31):7166-73.
2. Leonard PG, et al. Nat Chem Biol. 2016 Dec;12(12):1053-1058.
3. Muller FL, et al. Nature. 2012 Aug 16;488(7411):337-42.
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