Chemical Structure : Phosphosulindac
CAS No.:
1118973-90-2
Phosphosulindac
(Phospho-sulindac, OXT-328)
Catalog No.: PC-27218Not For Human Use, Lab Use Only.
Phosphosulindac (Phospho-sulindac, OXT-328) is a sulindac derivative and potential anti-cancer and anti-inflammatory agent, is effective in colon cancer and non-small-cell lung cancer (NSCLC).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Phosphosulindac (Phospho-sulindac, OXT-328) is a sulindac derivative and potential anti-cancer and anti-inflammatory agent, is effective in colon cancer and non-small-cell lung cancer (NSCLC).
Phosphosulindac (Phospho-sulindac, OXT-328) inhibits growth of cultured HCCCs and more efficacious in preventing the growth of HT-29 xenografts in nude mice.
Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts. phospho-sulindac suppressed lung tumorigenesis.
Phospho-sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice, inhibits EGFR-dependent survival cascades in NSCLC cells and induces oxidative stress to ultimately induce apoptosis/autophagy.
Physicochemical Properties
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M.Wt
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564.61
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Formula
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C28H34FO7PS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-((diethoxyphosphoryl)oxy)butyl (Z)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetate
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References
1. Xie G, et al. Br J Pharmacol. 2012 Apr;165(7):2152-66.
2. Mackenzie GG, et al. Gastroenterology. 2010 Oct;139(4):1320-32.
3. Sun Y, et al. Cancer Res. 2008 Oct 15;68(20):8269-77.
4. Cheng KW, et al. Mol Cancer Ther. 2013 Aug;12(8):1417-28.
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