You are here:Home-Chemical Inhibitors & Agonists-Others-Small GTPase-Phox-I2
Phox-I2

Chemical Structure : Phox-I2

CAS No.: 353495-22-4

Phox-I2

Catalog No.: PC-49776Not For Human Use, Lab Use Only.

Phox-I2 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=150 nM) and interferes with Rac1-GTP interaction with p67phox.

Packing Price Stock Quantity
5 mg $158 In stock
10 mg $238 In stock
25 mg $388 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Phox-I2 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=150 nM) and interferes with Rac1-GTP interaction with p67phox.
Phox-I2 is active in suppressing ROS production in both human and murine neutrophils.
Phox-I2 is effective in inhibiting NOX2-mediated superoxide production dose-dependently in human and murine neutrophils without detectable toxicity.
Phox-I2 inhibitedcollagen-induced platelet aggregation without affecting the tail bleeding time, inhibited in vivo platelet adhesion/accumulation at the laser injury sites on the saphenous vein without affecting the time for complete cessation of blood loss. 

Physicochemical Properties

M.Wt 337.34
Formula C18H15N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3a,4,5,9b-Tetrahydro-8-nitro-4-(3-nitrophenyl)-3H-cyclopenta[c]quinoline

References

1. Emily E Bosco, et al. Chem Biol. 2012 Feb 24;19(2):228-42.

2. H Akbar, et al. J Thromb Haemost. 2018 Oct;16(10):2083-2096.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: