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Piragliatin

Chemical Structure : Piragliatin

CAS No.: 625114-41-2

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Piragliatin (RO 4389620, R-1440)

Catalog No.: PC-61875Not For Human Use, Lab Use Only.

Piragliatin (RO 4389620, R-1440) is an allosteric, potent Glucokinase (GK) activator with SC1.5 of 0.18 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Piragliatin (RO 4389620, R-1440) is an allosteric, potent Glucokinase (GK) activator with SC1.5 of 0.18 uM.
    Piragliatin lowers pre- and postprandial glucose levels, improves the insulin secretory profile, increases β-cell sensitivity to glucose, and decreases hepatic glucose in vivo.

    Physicochemical Properties

    M.Wt 421.896
    Formula C19H20ClN3O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2R)-2-(3-Chloro-4-(methylsulfonyl)phenyl)-3-((1R)-3-oxocyclopentyl)-N-pyrazinylpropanamide

    References

    1. Sarabu R, et al. J Med Chem. 2012 Aug 23;55(16):7021-36.

    2. Bonadonna RC, et al. J Clin Endocrinol Metab. 2010 Nov;95(11):5028-36.

    3. Zhi J, et al. J Clin Pharmacol. 2016 Feb;56(2):231-8.

    4. Kim MK, et al. PLoS One. 2013 Sep 19;8(9):e73340.

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