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Chemical Structure : Piragliatin
Catalog No.: PC-61875Not For Human Use, Lab Use Only.
Piragliatin (RO 4389620.
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Piragliatin (RO 4389620;R-1440) is an allosteric, potent Glucokinase (GK) activator with SC1.5 of 0.18 uM; lowers pre- and postprandial glucose levels, improves the insulin secretory profile, increases β-cell sensitivity to glucose, and decreases hepatic glucose in vivo.
Diabetes
Phase 2 Discontinued
| M.Wt | 421.896 | |
| Formula | C19H20ClN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sarabu R, et al. J Med Chem. 2012 Aug 23;55(16):7021-36.
2. Bonadonna RC, et al. J Clin Endocrinol Metab. 2010 Nov;95(11):5028-36.
3. Zhi J, et al. J Clin Pharmacol. 2016 Feb;56(2):231-8.
4. Kim MK, et al. PLoS One. 2013 Sep 19;8(9):e73340.
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