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Piritrexim

Chemical Structure : Piritrexim

CAS No.: 72732-56-0

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Piritrexim (BW 301U, NSC 351521)

Catalog No.: PC-26914Not For Human Use, Lab Use Only.

Piritrexim (BW301U) is a lipophilic antifolate and potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC50 of 0.038 and 0.011 uM, respectively, shows antiparasitic, antipsoriatic and antitumor properties.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Piritrexim (BW301U) is a lipophilic antifolate and potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC50 of 0.038 and 0.011 uM, respectively, shows antiparasitic, antipsoriatic and antitumor properties.

Physicochemical Properties

M.Wt 325.37
Formula C17H19N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(2,5-Dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine

References

1. Rosowsky A, et al. J Med Chem. 1993 Oct 15;36(21):3103-12.

2. Sedwick WD, et al. Mol Pharmacol. 1982 Nov;22(3):766-70.

3. Grivsky EM, et al. J Med Chem. 1980 Mar;23(3):327-9. doi: 10.1021/jm00177a025.

4. de Vries EG, et al. Br J Cancer. 1993 Sep;68(3):641-4.

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