Chemical Structure : Pitavastatin
CAS No.:
147511-69-1
Pitavastatin
(NK-104)
Catalog No.: PC-25633Not For Human Use, Lab Use Only.
Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase (HMGCR) inhibitor, inhibits cholesterol synthesis from acetic acid with IC50 of 5.8 nM in HepG2 cells, induces hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor, possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase (HMGCR) inhibitor, inhibits cholesterol synthesis from acetic acid with IC50 of 5.8 nM in HepG2 cells, induces hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor, possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects.
Physicochemical Properties
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M.Wt
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421.47
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Formula
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C25H24FNO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid
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References
1. Aoki T, et al. Arzneimittelforschung. 1997 Aug;47(8):904-9.
2. Kitahara M, et al. Jpn J Pharmacol. 1998 Jun;77(2):117-28.
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