Pixantrone | Topo II inhibitor, MCM2 inhibitor

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Chemical Structure : Pixantrone

CAS No.: 144675-97-8

Pixantrone (BBR2778)

Catalog No.: PC-22736Not For Human Use, Lab Use Only.

Pixantrone (BBR2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator with anti-tumor activity, also is a direct mini-chromosome maintenance protein 2 (MCM2) inhibitor, induces cell cycle arrest and apoptosis in ovarian cancer cells via targeting MCM2.

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25 mg	$138	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Physicochemical Properties

M.Wt	557.52
Formula	C25H27N5O10
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6,9-Bis((2-aminoethyl)amino)benzo[g]isoquinoline-5,10-dione dimaleate

References

1. Chen Q, et al. Eur J Pharmacol. 2024 Jul 18:176835.et al.

2. Beeharry N, et al. Cancer Biol Ther. 2015;16(9):1397-406.

3. Hasinoff BB, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):397-409.

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Pixantrone (BBR2778)

Biological Activity

Physicochemical Properties

References

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