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Chemical Structure : Pladienolide B
Catalog No.: PC-21086Not For Human Use, Lab Use Only.
Pladienolide B is a potent inhibitor targeting the SF3B1 subunit of the spliceosome, exerts antitumor activities mediated through the inhibition of pre-mRNA splicing.
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Pladienolide B is a potent inhibitor targeting the SF3B1 subunit of the spliceosome, exerts antitumor activities mediated through the inhibition of pre-mRNA splicing.
Pladienolide B inhibits human cervical carcinoma cells viability, and induces apoptosis.
Pladienolide B reduces SF3b1 expression in human cervical carcinoma cells, causes cell cycle arrest and apoptosis.
Pladienolide B has shown strong inhibitory effect against activity and growth of various cell lines via targeting SF3b.
| M.Wt | 550.73 | |
| Formula | C31H50O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Effenberger KA, et al. J Biol Chem. 2014 Jan 24;289(4):1938-47.
2. Aouida M, et al. Biochim Open. 2016 Feb 24;3:72-75.
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