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Chemical Structure : Plecstatin-1
Catalog No.: PC-22649Not For Human Use, Lab Use Only.
Plecstatin-1 is a specific ruthenium(arene) pyridinecarbothioamide targeting plectin, affects cytoarchitecture and shape of keratinocytes, inhibits tumor invasiveness.
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Plecstatin-1 is a specific ruthenium(arene) pyridinecarbothioamide targeting plectin, affects cytoarchitecture and shape of keratinocytes, inhibits tumor invasiveness.
Plectin is a scaffold protein and an important cytolinker that regulates keratin and tubulin networks.
Plecstatin-1 induced higher levels of reactive oxygen species (ROS) in HCT116 cells.
Plecstatin-1 showed anticancer activity against primary tumors in CT-26 colon and more so in the invasive B16 melanoma tumor model after oral administration.
| M.Wt | 538.47 | |
| Formula | C22H23Cl2FN2RuS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Meier SM, et al. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8267-8271.
2. Wernitznig D, et al. Metallomics. 2020 Dec 23;12(12):2121-2133.
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