Chemical Structure : Plecstatin-1
CAS No.:
2119725-22-1
Plecstatin-1
(Plecstatin 1)
Catalog No.: PC-22649Not For Human Use, Lab Use Only.
Plecstatin-1 is a specific ruthenium(arene) pyridinecarbothioamide targeting plectin, affects cytoarchitecture and shape of keratinocytes, inhibits tumor invasiveness.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Plecstatin-1 is a specific ruthenium(arene) pyridinecarbothioamide targeting plectin, affects cytoarchitecture and shape of keratinocytes, inhibits tumor invasiveness.
Plectin is a scaffold protein and an important cytolinker that regulates keratin and tubulin networks.
Plecstatin-1 induced higher levels of reactive oxygen species (ROS) in HCT116 cells.
Plecstatin-1 showed anticancer activity against primary tumors in CT-26 colon and more so in the invasive B16 melanoma tumor model after oral administration.
Physicochemical Properties
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M.Wt
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538.47
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Formula
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C22H23Cl2FN2RuS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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[Cl-].FC1=CC=C(C=C1)NC2=[S][Ru+2]34567([Cl-])([N]=8C=CC=CC28)[CH]=9[CH]7=C6(C(C)C)[CH]5=[CH]4C93C
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References
1. Meier SM, et al. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8267-8271.
2. Wernitznig D, et al. Metallomics. 2020 Dec 23;12(12):2121-2133.
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