Chemical Structure : Plecstatin-1 hydrochloride
CAS No.:
Plecstatin-1 hydrochloride
Catalog No.: PC-22650Not For Human Use, Lab Use Only.
Plecstatin-1 hydrochloride is a specific ruthenium(arene) pyridinecarbothioamide targeting plectin, affects cytoarchitecture and shape of keratinocytes, inhibits tumor invasiveness.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Plecstatin-1 hydrochloride is a specific ruthenium(arene) pyridinecarbothioamide targeting plectin, affects cytoarchitecture and shape of keratinocytes, inhibits tumor invasiveness.
Plectin is a scaffold protein and an important cytolinker that regulates keratin and tubulin networks.
Plecstatin-1 induced higher levels of reactive oxygen species (ROS) in HCT116 cells.
Plecstatin-1 showed anticancer activity against primary tumors in CT-26 colon and more so in the invasive B16 melanoma tumor model after oral administration.
Physicochemical Properties
|
M.Wt
|
574.93
|
|
Formula
|
C22H24Cl3FN2RuS
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
[Cl-].FC1=CC=C(C=C1)NC2=[S][Ru+2]34567([Cl-])([N]=8C=CC=CC28)[CH]=9[CH]7=C6(C(C)C)[CH]5=[CH]4C93C
|
References
1. Meier SM, et al. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8267-8271.
2. Wernitznig D, et al. Metallomics. 2020 Dec 23;12(12):2121-2133.
Contact Us
sales@probechem.com
