Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-Plocabulin
Plocabulin

Chemical Structure : Plocabulin

CAS No.: 960210-99-5

Plocabulin (PM060184, PM-060184)

Catalog No.: PC-35334Not For Human Use, Lab Use Only.

Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM.
    Plocabulin inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells.
    Plocabulin also shows antifungal activity virtually abolishing growth of the filamentous fungus Aspergillus nidulans.

    Physicochemical Properties

    M.Wt 571.715
    Formula C31H45N3O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    [(1Z,4S,6Z)-1-[[(2S)-2-[[(2Z,4Z,6E,8S)-8-[(2S)-5-methoxy-6-oxo-2,3-dihydropyran-2-yl]-6-methylnona-2,4,6-trienoyl]amino]-3,3-dimethylbutanoyl]amino]octa-1,6-dien-4-yl] carbamate

    References

    1. Galmarini CM, et al. BMC Cancer. 2018 Feb 7;18(1):164.

    2. Pantazopoulou A, et al. Sci Rep. 2018 Jun 5;8(1):8616.

    3. Pera B, et al. ACS Chem Biol. 2013 Sep 20;8(9):2084-94.

    4. Prota AE, et al. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: