Pma1 inhibitor Si01

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Chemical Structure : Pma1 inhibitor Si01

Catalog No.: PC-24842Not For Human Use, Lab Use Only.

Pma1 inhibitor Si01 is a specific inhibitor of P-type H+-ATPase (proton) Pma1 inhibitor, extends the chronological lifespan (CLS) in fission yeast.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Pma1 inhibitor Si01 is a specific inhibitor of P-type H+-ATPase (Proton) Pma1 inhibitor, extends the chronological lifespan (CLS) in fission yeast.
Si01 inhibits Pma1 ATPase activity in fission yeast and budding yeast.
Si01 directly inhibits Pma1 of fission yeast which causes the reduction of glucose uptake into the cells.
Si01 reduces the activity of purified Pma1 protein and extends the CLS of not only fission yeast but also budding yeast.

Physicochemical Properties

M.Wt	356.42
Formula	C19H17FN2O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(((2,5-dimethylphenyl)amino)methyl)-5-(2-fluorobenzylidene)thiazolidine-2,4-dione

References

1. Lee AY, et al. Science. 2014 Apr 11;344(6180):208-11.

2. Tamura M, et al. Mol Genet Genomics. 2025 Jun 8;300(1):58.

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