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Chemical Structure : Polmacoxib
CAS No.: 301692-76-2
Catalog No.: PC-63065Not For Human Use, Lab Use Only.
Polmacoxib (CG-100649) is a novel NSAID proposed to inhibit both COX-2 and carbonic anhydrase (CA)-I/-II.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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Polmacoxib (CG-100649) is a novel NSAID proposed to inhibit both COX-2 and carbonic anhydrase (CA)-I/-II.
Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.
Polmacoxib induces the G2/M cell cycle arrest in colon cancer cells, and inhibits the tumor growth in colon cancer xenograft in nude mice.
| M.Wt | 361.39 | |
| Formula | C12H16FNO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(3-(3-fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide |
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1. Skarke C, et al. Clin Pharmacol Ther. 2012 Jun;91(6):986-93.
2. Kim SH, et al. Invest New Drugs. 2014 Dec;32(6):1105-1112.
3. Woo JK, et al. Oncol Rep. 2015 Apr;33(4):1947-55.
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