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Chemical Structure : Poloxin-2
Catalog No.: PC-60180Not For Human Use, Lab Use Only.
Poloxin-2 (Poloxin 2) is a potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM.
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Poloxin-2 (Poloxin 2) is a potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM.
Poloxin-2 shows >10-fold selectivity over Plk2 PBD and Plk3 PBD.
Poloxin-2 significantly improved potency and selectivity over Poloxin (Cat# PC-62393).
Poloxin-2 induces mitotic arrest and apoptosis in cultured human tumor cells at low micromolar concentrations.
| M.Wt | 269.3 | |
| Formula | C16H15NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Scharow A, et al. ACS Chem Biol. 2015 Nov 20;10(11):2570-9.
2. Scharow A, et al. Chembiochem. 2016 Apr 15;17(8):759-67.
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