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Polyoxyethylene stearate

Chemical Structure : Polyoxyethylene stearate

CAS No.: 9004-99-3

Polyoxyethylene stearate (PS40)

Catalog No.: PC-42403Not For Human Use, Lab Use Only.

Polyoxyethylene stearate (PS40) is a non-ionic emulsifying agent that can modulate multidrug resistance and enhances antitumor activity of vinblastine sulfate by modulating substrate-stimulated P-gp ATPase activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Polyoxyethylene stearate (PS40) is a non-ionic emulsifying agent that can modulate multidrug resistance and enhances antitumor activity of vinblastine sulfate by modulating substrate-stimulated P-gp ATPase activity.
Polyoxyethylene stearate inhibits P-gp mediated efflux in a concentration-dependent manner in Caco-2 cells.
Polyoxyethylene stearate also shows potential inhibitory activitites agasint CYP2C9 and CYP2C19.

Physicochemical Properties

M.Wt 725.00284
Formula (C2H4O)10C18H36O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 49 mg/mL

Chemical Name/SMILES

Poly(oxy-1,2-ethanediyl), α-(1-oxooctadecyl)-ω-hydroxy-

References

1. Cutler RR, et al. Tubercle. 1987 Sep;68(3):209-20.

2. Luo L, et al. AAPS J. 2007 Oct 5;9(3):E329-35.

3. Zhu S, et al. Eur J Pharm Sci. 2009 Jul 12;37(5):573-80.

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