PonatiLink-2

Chemical Structure : PonatiLink-2

Catalog No.: PC-28325Not For Human Use, Lab Use Only.

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Biological Activity

PonatiLink-2 is a potent, specific bitopic ABL1 inhibitor (IC50<10 nM) with improved selectivity and enhanced potency against resistance mutations (E255V/T315I, T315M, V468F), is highly potent against drug-resistant BCR::ABL1-mutant cells.
PonatiLink-2 is highly selective across the kinome and in cells.
PonatiLink-2 improves suppression of both wild-type BCR::ABL1 and ponatinib-resistant leukaemia in vivo.
PonatiLink-2 is highly effective against active-site resistance mutants, even those resistant to ponatinib.
PonatiLink-2 inhibits phosphorylation of ABL1 (p-ABL1(Y245)) and its known targets STAT5 (p-STAT5(Y694)) and CRKL (p-CRKL(Y207)) in cells expressing BCR::ABL1E255V/T315I.

Physicochemical Properties

M.Wt	1840.42
Formula	C89H120ClF5N12O22
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(chlorodifluoromethoxy)phenyl)-6-(4-((54-((3-((2-methyl-5-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)phenyl)ethynyl)imidazo[1,2-a]pyridin-7-yl)oxy)-33-oxo-3,6,9,12,15,18,21,24,27,30,37,40,43,46,49,52-hexadecaoxa-34-azatetrapentacontyl)carbamoyl)piperidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide

References

1. Stevenson JW, et al. Nature. 2026 Sep 23. doi: 10.1038/s41586-026-11056-8.

PonatiLink-2

Biological Activity

Physicochemical Properties

References

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